By Kolio D. Troev
Phosphonic acid esters are intermediates within the synthesis of significant sessions of compounds equivalent to alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of every of those compound periods is reviewed in detail.
Alpha-Aminophosphonic acids are a big type of biologically energetic compounds, that have bought an expanding volume of consciousness simply because they're thought of to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic brokers are good documented. Alpha-Hydroxyalkanephosphonates are compounds of important organic and medicinal purposes. Dialkyl epoxyalkylphosphonates are of curiosity due to their use as intermediates within the synthesis of bioactive ingredients, and as modifiers of traditional and artificial polymers. Bisphosphonates are medicinal drugs which were customary in numerous bone ailments, and feature lately been used effectively opposed to many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of gear. Nucleoside H-phosphonates appear to be the main appealing applicants as beginning fabrics within the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido-2’,3’-dideoxythimidine is without doubt one of the most vital anti-HIV prodrug, that's at the moment in scientific trials.
Chapters evaluation the synthesis; actual and spectral homes (1H, 13C, 31P and 17O NMR data); attribute reactions; vital periods of compounds according to those esters of H-phosphonic acid; their program as physiologically lively elements, flame retardants, catalysts, warmth and light stabilizers, lubricants, scale inhibitors, polymer-carriers of medications; practise of H-phosphonate diesters and common strategies for undertaking an important reactions.
* presents rules for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)
* experiences constitution, spectra and organic task of H-phosphonates and their derivatives
* examines new components of software of phosphorus-containing compounds
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Chemistry and Application of H-Phosphonates by Kolio D. Troev