By Amy M. Fulton
Chemokines are a superfamily of low molecular weight cytokines that have been firstly defined in line with their skill to urge the directed migration of leukocytes to websites of irritation or harm. In people, there are nearly forty five chemokines that bind to 19 G-protein-coupled receptors. as well as mediating mobile migration, chemokines have now been proven to impact many mobile services together with survival, adhesion, invasion, proliferation, and to control circulating chemokine degrees. even if chemokine receptors have been first defined on leukocytes, it truly is now liked that chemokine receptors also are expressed via many different cells together with endothelial and epithelial cells.
Since the 1st description of chemokine receptors on malignant cells in 2001, an intensive literature has constructed describing the expression and serve as of chemokine receptors in lots of malignancies. those reviews help the preliminary speculation that malignant cells use chemokine receptors emigrate to far away websites of ligand expression and that expression of definite receptors is linked to a bad diagnosis. It has additionally develop into obvious that malignancies of other tissues may well use a various profile of chemokine receptors and that an identical receptor may possibly mediate metastasis to assorted websites in tumors of other histological origins. Receptor functionality can also keep survival and enlargement of the first tumor.
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Chemokine Receptors in Cancer (Cancer Drug Discovery and Development) by Amy M. Fulton